Diagnostic Accuracy of Mammography in Symptomatic Patients at Civil Hospital, Karachi

Authors

  • Rehana Shaikh Dow Univeristy of Health Sciences/Civil Hospital Karachi
  • Ateeque Ahmed Khan Department of Radiology, Civil Hospital, Dow University of Health Sciences, Karachi, Pakistan.

Keywords:

Mammography, Breast Lumps, Nipple discharge, Breast pain, Histopathology, Breast cancer

Abstract

Objective: To analyze the diagnostic accuracy of mammography in symptomatic patients by using histopathology as a gold standard.
Material and Methods: This was a Descriptive Cross-Sectional Study, done in the Radiology Department, Dow University of Health Sciences/Civil Hospital Karachi, over a period of one year. This study includes 140 patients with sign/symptoms of breast disease referred to our department for mammography. Patients were selected according to study criterion. Mammography was performed after taking detailed history and breast examination.
Mammograms were interpreted by consultant radiologist and final diagnosis of the lesion on mammography had made which was compared with the histopathology. The primary performance outcomes of diagnostic mammography like sensitivity, specificity, accuracy, positive and negative predictable values were calculated.
Results: Mean age of the patients was 48.42 ±10.5years. Out of 140 patients, 91 (65%) showed malignant lesions while 49 (35%) having benign lesions. 85 patients out of 91 (93.4%) who labeled as malignant on mammography were proven malignant on histopathology and 41 patients out of 49 (83.6%) who labeled as benign on mammography were came out benign on histopathology. This study showed the sensitivity of 91.3%, specificity of 87.2% and accuracy of 90% when mammographic diagnosis was compared with gold standard histopathology.
Conclusion: Breast cancer is the most common and potentially curable disease, and the mammogram is an important tool for its diagnosis so there is dire need of mammographic set up all over the Pakistan to detectbreast cancer early and reduce mortality

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References

Sainsbury R. The breast. In: Williams NS, Bulstrode CJK, O’ Connell PR editors. Bailey and Love’s Short

practice of surgery. London: Edward Arnold publishers ;2008..827-48.

Gilani GM, Kamal S, Akhtar AS. A differential study of breast cancer patients in Punjab, Pakistan.J Pak Med Assoc 2003;53:478-81.

Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics 2005. CA Cancer J

Clin 2005;55:10-30.

Siddiqui K, Rasool MI. Patterns of breast disease: prelimi nary report of breast clinic. J Coll Physicians Surg Pak

;11:497-500.

Houssami N,Irwig L, Simpson JM McKessar M, Blome S, Noakes J. Sydney breast imaging accuracy study: comparative sensitivity and specificity ofmammographyand sonography in young women with symptoms. Am J Roentgenol 2003;180:935-40.

White E, Velentgas P, Mandelson MT, Lehman CD, Elmore JG, Porter P et al. Variation in mammographic breast density by time in menstrual cycle among women aged 40-49 years. J Natl Cancer Inst 1998;90:906-10.

Ma L, Fishell E, Wright B, Hanna W, Allan S, Boyd NF. Case-control study of factors associated with failure to detect breast cancer by mammography. J Natl Cancer Inst 1992;84:781–5.

Kolata G.The New York Times: Mammograms validated as key in cancer fight online 1981 cited 2005 0ctober 27. Available from: URL:

Thulkar S, Hari S. Present Role of Mammography/Digital Mammography in Breast Cancer Management. PET

Clin. 2009;4:213-25. doi: 10.1016/j.cpet.2009.09.006.

Jalali U, Rasul S, Khan TMA. Sensitivity and specificity of Mammography according to Bi-Rads scoring in sympt

omatic patients. J Surg Pak 2004;9:32-5.

Moskowitz M. Breast cancer: age specific growth rates. Cancer 1994;5:12-5.

Isaac U, Memon F, Nishatn Z.Frequency of breast diseas es at a tertiary hospital of Karachi. J Liaquat Uni Med Health Sci 2005;4:6-9.

Sidhartha, Thapa B, Singh Y, Sayami P, Khanal U. Mam-mographic diagnosis of breast carcinoma:an institutional

experience. J Nepal Med Assoc 2008;47:62-5.

Siyal AR, Shaikh SM,Baloach QD,Rathi SL, Chand H. Pattern of breast cancer in women of upper Sindh. Pak J Pathol 1998;9:14-7.

Ohuchi N,Suzuki A,Sobue T,Kawai M, Yamamoto S, Zheng YF, et al. Sensitivity and specificity of mammo

graphy and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomi

zed Trial (J-START): a randomised controlled trial. Lancet.2016;387:341-8. doi:10.1016/S0140-673600774-6.

Duijm LE, Guit GL, Zaat JO, Koomen AR, Willebrand D. Sensitivity, specificity and predictive values of breast

imaging in the detection of cancer. Br J Cancer 1997;76:377-81.

Yankaskas BC, Gill KS. Diagnostic mammography performance and race: outcomes in Black and White women. Cancer 2005;104:2671-81.

Eltahir A, Jibril JA, Squair J, Heys SD, Ah-See AK,Need ham G et al. The accuracy of "one-stop" diagnosis for 1,110 patients presenting to a symptomatic breast clinic.JR Coll Surg Edinb 1999;44:226-30.

Flobbe K, van der Linden ES, Kessels AG, van Engel shoven JM. Diagnostic value of radiological breast imag

ing in a nonscreening population. Int J Cancer 2001 ;92:616-8.

Zhi H, MD, Ou B, Luo BM, Feng X, Wen YL, YangHY. Comparison of ultrasound elastography, mammography,

and sonography in the diagnosis of solid breast lesions. J Ultrasound Med 2007;26:807–15.

Barlow WE, Lehman CD, Zheng Y, Ballard-BarbashR, Yankaskas BC, Cutter GR et al. Performance of Diagnos

tic Mammography for Women With Signs or Symptoms of Breast Cancer. J Natl Cancer Inst 2002;94:1151–9.

Saarenmaa I, Salminen T, Geiger U, Heikkinen P, Hyvari nen S, Isola J et al. The effect of age and density of the

breast on the sensitivity of breast cancer diagnostic by mammography and ultasonography. Breast Cancer Res

Treat 2001;67:117-23.

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Published

2017-08-29

How to Cite

Shaikh, R., & Khan, A. A. (2017). Diagnostic Accuracy of Mammography in Symptomatic Patients at Civil Hospital, Karachi. Journal of the Dow University of Health Sciences (JDUHS), 11(2), 41–45. Retrieved from https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/1385

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