Clinical Patterns and Risk Factors Associated With Pigmented Purpuric Dermatoses
DOI:
https://doi.org/10.36570/jduhs.2021.2.1091Keywords:
Schamberg's disease, Body mass index, Comorbidity, Pigmented purpuric dermatoses, Venous insufficiencyAbstract
Objectives: Authors aimed to investigate clinical patterns, characteristics and risk factors associated with pigmented purpuric dermatoses (PPD) in Pakistani population and to correlate the relationship of various suggested aetiologic agents with PPD in our population.
Methods: Retrospective analysis of 65 patients was done who visited The Indus Hospital, Karachi between October 2017 to March 2020. Demographics, comorbids, body mass index (BMI), PPD type, clinical findings, laboratory parameters and ultrasonographic findings (USF) of both lower limbs for venous insufficiency were reviewed.
Results: Mean age of patients was 42.6±13.9 years with male to female ratio of 1.2:1. Majority were housewives (40.3%). Schamberg’s disease was present in 64.6%. Obesity was present in 78.1%. Reflux in superficial venous system in 52.3% on ultrasonography, detectable dilated veins in 58.5% and presence of venous stasis in 30.8% PPD cases were found. Males were twice more commonly affected with varicosities. Hypertension (46.2%), diabetes (27.8%) and hyperlipidemia (18.5%) were most common comorbids. Statistically significant differences were detected between USF (p=0.01) and clinical varicosities (p=0.04) when Schamberg’s disease and other PPD were compared; while no association was found with respect to age, gender, occupation, BMI and type of comorbids in these two groups.
Conclusion: Venous insufficiency, obesity, and comorbidities like hypertension, diabetes and hyperlipidemia were main cofactors linked with PPD in our population.
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References
Garg A, Callen J, Ofori AO. Pigmented purpuric dermatoses (capillaritis) [Internet]. 2010 [updated 2020 Jan 21; cited 2021 Jan 5. Available from https://www.uptodate.com/contents/pigmented-purpuric-dermatoses-capillaritis
Mallick YA, Hussain SA. Frequency of chronic venous insufficiency in patients of Schamberg’s disease. J Pak Assoc Dermatol 2019;29(1):45-50.
Ehsani AH, Ghodsi SZ, Nourmohammad-Pour P, Aghazadeh N, Damavandi MR. Pigmented purpura dermatosis and viral hepatitis: a case-control study. Australas J Dermatol 2013;54(3):225-7. doi: 10.1111/ajd.12003
Sethuraman G, Sugandhan S, Bansal A, Das AK, Sharma VK. Familial pigmented purpuric dermatoses. J Dermatol 2006;33(9):639-41. doi: 10.1111/j.1346-8138.2006.00149.x
Sardana K, Sarkar R, Sehgal VN. Pigmented purpuric dermatoses: an overview. Int J Dermatol 2004;43:482–8. doi: 10.1111/j.1365-4632.2004.02213.x
Hercogova J. Persistent pigmented purpuric dermatoses: who are you? J Eur Acad Dermatol Venereol 2001;15(1):15. doi: 10.1046/j.1468-3083.2001.00199.x
Hoesly FJ, Huerter CJ, Shehan JM. Purpura annularis telangiectodes of Majocchi: case report and review of the literature. Int J Dermatol 2009;48(10):1129-33.
doi: 10.1111/j.1365-4632.2009.04160.x
Gönül M, Çakmak SK, Özcan N, Oğuz ID, Gül U, Bıyıklı Z. Clinical and laboratory findings of pigmented purpuric dermatoses. Ann Dermatol 2014;26(5):610-4. doi: 10.5021/ad.2014.26.5.610
Ozkaya DB, Emiroglu N, Su O, Cengiz FP, Bahali AG, Yildiz P, et al. Dermatoscopic findings of pigmented purpuric dermatosis. An Bras Dermatol 2016;91(5):584–7. doi: 10.1590/abd1806-4841.20165124
Sharma L, Gupta S. Clinicoepidemiological study of pigmented purpuric dermatoses. Indian Dermatol Online J 2012;3(1):17-20. doi: 10.4103/2229-5178.93486
Kim DH, Seo SH, Ahn HH, Kye YC, Choi JE. Characteristics and clinical manifestations of pigmented purpuric dermatoses. Ann Dermatol 2015;27(4):404-10. doi: 10.5021/ad.2015.27.4.404
Huang YK, Lin CK, Wu YH. The pathological spectrum and clinical correlation of pigmented purpuric dermatosis-A retrospective review of 107 cases. J Cutan Pathol 2018;45(5):325-32. doi: 10.1111/cup.13118
Metin MS, Elmas OF. Dermoscopic profile of pigmented purpuric dermatosis: new observations. Postepy Dermatol Alergol 2019;36(6):687–91. doi: 10.5114/ada.2019.91419
Cho JH, Lee JD, Kang H, Cho SH. The clinical manifestations and etiologic factors of patients with pigmented purpuric dermatoses. Korean J Dermatol 2005;43:45-52.
Dessoukey MW, Abdel-Dayem H, Omar MF, Al-Suweidi NE. Pigmented purpuric dermatosis and hepatitis profile: a report on 10 patients. Int J Dermatol 2005;44:486-488.
doi: 10.1111/j.1365-4632.2005.02045.x
Tato BP, Escobedo SM, Gonzalez YCP, Albisua BS, Olabarrieta IP, Mayoral BE, Lopez PF. Granulomatous variant of pigmented purpuric dermatosis. Am J Dermatopathol 2012;34(7):746-8. doi: 10.1097/DAD.0b013e31823f616a
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Copyright (c) 2021 Yousuf Abd Mallick, Ahsun Jiwani
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