Association of Nutritional Status and Serum Leptin in Offsprings of Diabetic Parents of Karachi, Pakistan

Authors

  • Meraj Rahim Department of Physiolog, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan
  • Mariam Rahim Department of Physiology/1 Graduate, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan
  • Munim Abdul Rahim Graduate, Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences Dow University of Health Sciences, Karachi, Pakistan
  • Mozaffer Rahim Hingorjo Jinnah Medical & Dental College, Karachi, Pakistan.
  • Shaheen Sharafat Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  • Zaman Shaikh South City Hospital, Karachi, Pakistan.
  • Masood Anwar Qureshi Department of Physiology, Dow University of Health Sciences, Karachi, Pakistan.

Keywords:

Serum leptin, type 2 diabetes mellitus, BMI

Abstract

Objective:

Prevalence of diabetes in Pakistan in the year 2014 was 6.9 million and is expected to rise to approximately 13 million in 2035, ranking Pakistan at 8th position among world's top 10 countries having diabetes.

Materials and Methods:

The study design is young subjects were taken aged 18 to 24 and were classified according to their family history of type 2 diabetes mellitus (T2DM) into those with single diabetic parent (SDP), both diabetic parents (BDP) and subjects having no family history of diabetes (NDP). Body composition was assessed by measuring body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR). Fasting venous blood was analyzed for glucose and leptin levels (measured by immunoenzymetric assay).

Results:

The offspring of BDP had significantly higher body weight as compared to those of SDP and NDP (p<0.05). The mean fasting serum leptin levels among NDP, SDP and BDP were significantly different (p<0.05), and were respectively, 4.91±6.78, 15.55±13.49 and19.04 ±14.57 ng/mL.

Conclusion:

Hyperleptinemia and anthropometric indices are the most prominent indicators of T2DM in individuals with a history of diabetes in the family

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References

International diabetes federation. diabetes atlas. sixth edition 2013. [Cited on January 22, 2015.] Availabe from URL: http://www.idf.org/diabetesatlas

Shera AS, Jawad F, Maqsood A. Diabetes research and clinical practise 2007; 76:219-22.

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372:425-32.

Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. Faseb J 2002; 16:1163-76.

Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J: Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 2001; 283:982-8.

Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 2001; 276:6343-49.

Chen H, Charlat O, Tartaglia LA. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84:491-5.

Zhang Y, Scarpace PJ. The role of leptin in leptin resistance and obesity. Physiol Behav 2006; 88:249-56.

Scarpace PJ, Matheny M, Tumer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 2001; 104:1111-7.

Shera AS, Rafique G, Khwaja IA, Ara J, Baqai S, King H et al. Pakistan national diabetes survey:prevalence of glucose intolerance and associated factors in Shikarpur, Sindh Province Diabet Med 1995.

World Health Organization. The asia pacific perspective: redefining obesity and its treatment. Health communication Australia. Int Obesity Task Force 2000.

Rahim M, Rahim M, Qureshi MA, Sharafat S, Shaikh Z, et al. Serum insulin and insulin resistance in the off-

springs of type 2 diabetes mellitus. J Diabetes Metab 2014; 5:425

Rahim M, Rahim M, Qureshi MA, Sharafat S, Shaikh Z, et al. Lipid profile and growth indicators among offspring’s of diabetic parents in Karachi, Pakistan. J Diabetes Metab 2014; 5:443.

Rahim M, Rahim M, Rahim M, Sharafat S, Shaikh Z, et al. Maternal and paternal transmission of diabetes: influence of nutritional factors. J Diabetes Metab 2015; 6:504.

Rahim M, Rahim M, Qureshi MA, Sharafat S,Shaikh Z. Frequency of prediabetes, raised BMI and low plasma HDL-cholesterol in offspring of diabetes. J Dow Uni Health Sci 2014; 8:67-71.

Shahid A, Lone KP, Saeed S, Arslan M. Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent. Hormones 2008; 7:313-19.

Mannucci E, Monami M, Cresci B. National cholesterol education program and international diabetes federation definitions of metabolic syndrome in the prediction of diabetes. Results from the firenze- bagno a ripoli study. Diabetes Obes Metab 2008; 10:430-5.

Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P, Tibblin G, et al. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular diseaseand death: 13 year follow up of participants in the study of men born in 1913. Br Med J (Clin Res Ed) 1984;

:1401-4.

Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjostrom L, et al. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden Br Med J (Clin Res

Ed) 1984; 289:1257-61.

Ducimetiere P, Richard J, Cambien F. The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris prospective study. Int J Obes 1986; 10:229-40.

Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000; 21:697-738.

Carr MC, Brunzell JD. Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab 2004; 89:2601-7.

Fruhbeck G, Aguado M, Martinez JA, In vitro lipolytic effect of leptin on mouse adipocytes: evidence for possible autocrine-paracrine role of leptin. Biochem Biophys Res Commun 1997; 240:590-4.

Frayling TM, Timpson NJ, Weedon MN. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316:889-94.

Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev 1994; 74:761-809.

Schmidt MI, Duncan BB, Canani LH, Karohl C, Chambless L. Association of waist–hip ratio with diabetes mellitus. Strength and possible modifiers. Diabetes Care 1992; 15:912-4.

Cassano PA, Rosner B, Vokonas PS, Weiss ST. Obesity and body fat distribution in relation to the incidence of non-insulin dependent diabetes mellitus. A prospective cohort study of men in the normative aging study. Am J Epidemiol 1992; 136:1474-86.

Wei M, Gaskill SP, Haffner SM, Stern MP. Waist circumference as the best predictor of noninsulin dependent diabetes compared to body mass index, waist / hip ratio and other anthropometric measurements in Mexican Americans 7-year prospective study. Obes Res

; 5:16-23.

Das UN. Exercise and inflammation. Eur Heart J 2006; 27:1385-6.

Das UN. Anti-inflammatory nature of exercise. Nutrition 2004; 20:323-6.

Burke GL, Savage PJ, Sprafka JM, Selby JV, Jacobs DR, Perkins LL, et al. Relation of risk factor levels in young adulthood to parental history of disease. The CARDIA study. Circulation 1991; 84:1176-87.

Zimmet P, Hodge A, Nicolson M. Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross-sectional study. BMJ 1996; 313:965-69.

Covey SD, Wideman RD, McDonald C. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 2006; 4:291-302.

Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 1991; 34:416- 22.

Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. nAnalysis of paradoxical observations on the association between leptin and insulin resistance. Faseb J 2002;16:1163-76.

Wannamethee SG, Lowe GD, Rumley A, Cherry L, Whincup PH, Sattar N, et al. Adipokines and risk of type 2 diabetes in older men. Diabetes Care 2007; 30:1200-5.

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Published

2021-10-07

How to Cite

Rahim, M., Rahim, M. ., Abdul Rahim, M. ., Rahim Hingorjo, M. ., Sharafat, S. ., Shaikh, Z. ., & Anwar Qureshi, M. . (2021). Association of Nutritional Status and Serum Leptin in Offsprings of Diabetic Parents of Karachi, Pakistan. Journal of the Dow University of Health Sciences (JDUHS), 10(2). Retrieved from https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/1396

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