Failure to Thrive, Can this be Bartter’s Syndrome?

Authors

  • Nighat Aijaz Department of Paediatrics, Liaquat National Hospital and Medical College, Karachi, Pakistan.
  • Saira Waqar Lone Department of Paediatrics, Liaquat National Hospital, Karachi, Pakistan.
  • Nasrul Huda Department of Paediatrics, Aga Khan University, Karachi, Pakistan.
  • S. Shakil Ahmed Rizvi Department of Paediatrics, Kharadar General Hospital, Karachi, Pakistan.
  • Abdul Gaffar Billoo Department of Paediatrics, Aga Khan University Hospital, Karachi, Pakistan.

Keywords:

Failure to thrive, Bartter’s Syndrome, Polyuria, Metabolic alkalosis.

Abstract

A case series of four children, of different age groups, having complaints of polyuria and failure to thrive. These cases include two infants, a toddler and a child and investigations revealed that they had hyponatremia, hypokalemia, hyperchloremia and metabolic alkalosis, leading to a diagnosis of Bartters syndrome. Two of the patients also had hypomagnesemia. All the children were put on treatment for Bartter’s Syndrome, and they responded well but unfortunately one of them was lost to follow-up.

Downloads

Download data is not yet available.

References

Katherine MD, Avner ED. Bartter/Gitelman Syndromes and Other Inherited Tubular Transport Abnormalities,

Kliegman: Nelson Textbook of Pediatrics, 18 ed: ch 531.

Bartter F, Pronove P, Gill J, Jr, MacCardle R. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism

and hypokalemic alkalosis. A new Syndrome. Am J Med 1962; 33:811-28.

Tomimatsu t, Fakuda H, Kanzaki T, Hirano S, Wada K, Murata Y. Neonatal Bartter Syndrome with unilateral multicystic dysplastic kidney disease. Pediatric Nephrol 2003; 18:391-3.

Rodrigues-Soriano J. Bartter’s Syndrome comes of age. Pediatrics 1999; 103:663-4.5 Bartter’s site: information and support for Bartter’s & Gitelman’s syndromes. www.barttersite.org/bartterssyndrome 2008.

Vost BA, avner ED. The kidney and the urinary tract in fanaroff aa, martin RJ (edi). Neonatal-perinatal

medicine disease of the fetus and infant. St. Louis, Missouri: Mosby 2002; p.1534.

Stein JH. The pathogenetic spectrum of Bartter's syndrome. Kidney Int 1985;28:85.

Ji W, Foo JN, O'Roak BJ. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 2008; 40:592.

Parkash J, Muhammad SS, Khan IA. Neonatal Bartter syndrome. J Coll Physicians Surg Pak 2006; 16:548-50.

Bhamkar RP, Gajendragadkar A. Antenatal Bartter's syndrome with sensorineural deafness Indian J Nephrol

; 19:23-6.

Kumar SM, Deenadayalan M, Janakiraman L, Vijayakumar M. Neonatal Bartter syndrome. Indian Pediatr 2006; 43:735-7.

Ramamurthy HR, Kanitkar M, Raju U. Bartter’s Syndrome masquerading as a neurometabolic disorder. Med J Armed Forces India 2007; 63:282-3.

Pal P. Bartter Syndrome. Child Newborn 2007; 11:75-7.

Vaisbisch MH, Fujimura MD. Bartter Syndrome: benefits and side effects of longterm. Pediatric Nephrolo

; 19:858-63.

Moureni CC, Sanjad SA, Aketcharian CY. Bartter Syndrome in a neonate: early treatment with indomethacin. PediatricNephr2000; 14:143-5.

Text book ofPaediatrics by Forfar Arneil pg. No. 605.

William MP, Jones CL, Johnston LM, Walker RG, Miradic DA, Powel HR. An extreme example of the neonatal form of Bartter’s Syndrome. Pediatric Nephrol 1996; 10:496-7.

Contractor CP, Mehta SD, Wagle SU, Desphande PG, Irani SF. Bartter’s syndrome: a neonatal presentation (a case report) J Postgrad Med 1992; 38:41-3.

Dillon MJ, Shah V, Mitchell MD. Bartter’s syndrome 10 cases in childhood results of long term indomethacin therapy. Q J Med 1979; 48:429-46.

Abdel-al YK, Badawi MH, Yaeesh SA, Habib YQ, alKhuffash FA, al-Ghanim MM, et al. Bartter’s syndrome in Arabic children: review of 13 cases. Pediatr Int 1999;41:299-303.

Ruvalcaba RH, Martinez FE. Familial growthhormone deficiency associated with Bartter’s Syndrome. Am J Med Sci 1992; 303:411-4.

Downloads

Published

2011-04-28

How to Cite

Aijaz, N. ., Lone, S. W., Huda, N. ., Rizvi, S. S. A., & Billoo, A. G. (2011). Failure to Thrive, Can this be Bartter’s Syndrome?. Journal of the Dow University of Health Sciences (JDUHS), 5(1), 37–40. Retrieved from https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/1534

Issue

Section

Case Series